Decorative Border


In Vitro Anthropomorphic Model of the Cerebrospinal Fluid System: Application to Subarachnoid Hemorrhage Filtration

June 25, 2019 - Lucas R. Sass, Mohammadreza Khani, et al

Complications following subarachnoid hemorrhage (SAH) such as delayed cerebral ischemia, vasospasm and hydrocephalus account for the poor prognosis and death of many patients. SAH releases blood into the cerebrospinal fluid (CSF) exposing the surrounding tissue to inflammatory clotting byproducts. Removal of blood via lumbar drain has been shown to positively impact clinical outcomes and the rapid removal of blood from the CSF is the target of a new device aimed at improving patient outcomes. The presented work outlines the assembly and testing of an in vitro platform modeling active clearance of SAH using a dual lumen catheter-based CSF filtration device.



Impact of Cerebrospinal Fluid Filtration on Subarachnoid Hemorrhage Clearance: A Computational Fluid Dynamics Study

June 25, 2019 - Summer Biomechanics, Bioengineering, and Biotransport Conference, Seven Springs, Pennsylvania - Mohammadreza Khani, Lucas R. Sass, et al

Subarachnoid hemorrhage (SAH) is a severe and often-fatal event in which blood is released into the cerebrospinal fluid (CSF) due to intracranial insult, ruptured intracranial aneurysm, and/or other head trauma. Early and rapid filtration of blood and blood breakdown byproducts post-SAH may reduce the incidence of stroke, and/or cerebral vasospasm. The study objective was to formulate a computational model to see the impact of the NeurapheresisTM system on CSF flow velocities, steady-streaming, and subarachnoid blood clearance by comparing it to a case with lumbar drain only.



Healthcare Economics of Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage in the United States

April 13, 2019 - American Association of Neurological Surgeons, San Diego, CA, Syed M. Adil, Beiyu Liu, et al

Aneurysmal subarachnoid hemorrhage (aSAH) is a common but devastating condition, with fatality rates of 8-61% in the 1-month after diagnosis. This poster quantifies the healthcare resource utilization (HCRU) and health economic burden incurred by the US health system due to post-aSAH hydrocephalus and perform a preliminary analysis regarding the effect of timing of permanent CSF diversion procedure (i.e. VP shunt or ETV) on cost.



Healthcare Economics of Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage in the United States

March 13, 2019 - Translational Stroke Research, Syed M. Adil, Beiyu Liu, et al

Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition’s high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health system due to post-aSAH hydrocephalus.



In Vitro Characterization of the Neurapheresis™ System for the Treatment of Cryptococcal Meningitis

February 5, 2018 - Duke University Medical Center/Minnetronix Neuro

Cryptococcal Meningitis is caused by Cryptococcus neoformans and is the most common cause of fungal meningitis in adults. Treatment for Cryptococcal Meningitis is based on an induction, consolidation, and maintenance approach with antifungals, but is associated with continued high morbidity and mortality. A catheter-based extracorporeal filtration system (Neurapheresis™ Therapy) for the filtration of infected CSF is a ...