Decorative Border

In Vitro Characterization of the Neurapheresis™ System for the Treatment of Cryptococcal Meningitis

February 5, 2018 - Duke University Medical Center/Minnetronix Neuro

Cryptococcal Meningitis is caused by Cryptococcus neoformans and is the most common cause of fungal meningitis in adults. Treatment for Cryptococcal Meningitis is based on an induction, consolidation, and maintenance approach with antifungals, but is associated with continued high morbidity and mortality. A catheter-based extracorporeal filtration system (Neurapheresis™ Therapy) for the filtration of infected CSF is a ...

Feasibility of Neurapheresis™ Therapy for Multidrug Resistant Gram-negative Bacterial Meningitis

October 4, 2017 - Duke University Medical Center/Minnetronix Neuro

Pseudomonas, Acinetobacter and Klebsiella are three multidrug resistant (MDR) gram-negative pathogens that pose a threat to human health. Patients in hospitals or nursing homes, and with devices such as intravenous catheters or ventilators are at increased risk of Gram-negative bacterial meningitis (GBM) from these bacteria. GBM manifests when these bacteria invade the central nervous system. Increasingly antibiotic resistant bacteria strains cause high mortality associated with...

A Novel Therapeutic Approach for Cryptococcal Meningitis

October 26, 2016 - Duke University School of Medicine/Minnetronix Neuro

Cryptococcal meningitis (CM) is a devastating opportunistic infection that primarily presents in immunocompromised patients. CM is caused when Cryptococcus neoformans, a basidiomycete fungal pathogen, invades the central nervous system (CNS) and circulates within cerebospinal fluid (CSF) around the brain and spinal cord in the subarachnoid space. Current treatment guidelines include two weeks of continuous intravenous administration of amphotericin B and flucytosine, and maintaining a fungicidal regimen for six months. The single most important factor impacting survival has been shown to be ...