In Vitro Characterization of the Neurapheresis™ System for the Treatment of Cryptococcal Meningitis

October 4, 2017 - Duke University Medical Center/Minnetronix Neuro



Cryptococcal Meningitis is caused by Cryptococcus neoformans and is the most common cause of fungal meningitis in adults. Treatment for Cryptococcal Meningitis is based on an induction, consolidation, and maintenance approach with antifungals, but is associated with continued high morbidity and mortality. A catheter-based extracorporeal filtration system (Neurapheresis™ Therapy) for the filtration of infected CSF is a potential alternate or adjunctive intervention. This poster, produced with Duke University describes the in vitro characterization of Neurapheresis™ Therapy as an alternative mechanical intervention for filtration of C. neoformans cells, polysaccharide antigen, and inflammatory mediators from infected CSF.

Lefko Charalambous, BS, Christi Ballard, BS, Tiffany Ejikeme, BS, Bilal Ashraf, BS, Promila Pagadala, PhD., Charles Giamberardino, MR, Blake Hedstrom, MA, Laura Zitella Verbick, PhD, Aaron McCabe, PhD, Shivanand P. Lad, MD, PhD and John R. Perfect, MD, FIDSA